Spectroscopic Characterization of Disulfiram and Nicotinic Acid after Biofield Treatment

نویسندگان

  • Mahendra Kumar Trivedi
  • Alice Branton
  • Dahryn Trivedi
  • Gopal Nayak
  • Khemraj Bairwa
  • Snehasis Jana
چکیده

Disulfiram [bis(diethylthiocarbamoyl)disulphide] is an antabuse drug, being used clinically as an aid to the treatment of chronic alcoholism. It is the first drug approved by US Food and Drug Administration to treat the alcohol addiction [1]. Alcohol (ethanol) transforms into acetaldehyde by alcohol dehydrogenase enzyme, which further oxidized to acetic acid by acetaldehyde dehydrogenase (ADH) enzyme [2]. Disulfiram inhibits the ADH enzyme. As a result, the blood concentration of acetaldehyde increases and causes an unpleasant effect, thus increase the patient's motivation to remain abstinent [3]. In addition to this, disulfiram is reported for protozoacidal effect in vitro study [4,5]. Recently, disulfiram has shown the reactivity to latent HIV1 expression in a primary cell model of virus latency and presently it is assessed in a clinical trial for its potential to diminish the latent HIV-1 reservoir in patients combination with antiretroviral therapy [6].

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تاریخ انتشار 2015